It also noted Oil Refineries is in the process ofimplementing an aggressive $1

It also noted Oil Refineries is in the process ofimplementing an aggressive $1.1 billion investment plan. Plasmazellen sind weiße Blutzellen, die die Produktion von Antikörpern(Immunglobuline) zur Bekämpfung von Infektionen und Krankheiten unterstützen.Die meisten Patienten mit multiplen Myelomen verfügen jedoch über Zellen, dieeine Form von Immunglobulin produzieren (Paraprotein oder M-Protein), die keineVorteile für den Körper bietet. InAustralien und Neuseeland ist REVLIMID in Kombination mit Dexamethason für dieBehandlung von Patienten zugelassen, deren Erkrankung nach einer Therapie weiterfortschritt. ?Der vom NICE erstellte FAD-Bericht ist einwichtiger Schritt in Richtung einer entscheidenden neuen Option für Patienten inGroßbritannien." REVLIMID® ist derzeit in der Europäischen Union, den Vereinigten Staaten,Kanada, der Schweiz und in bestimmten lateinamerikanischen Ländern inKombination mit Dexamethason für die Behandlung von Patienten mit multiplemMyelom zugelassen, die mindestens eine frühere Therapie durchgemacht haben. Neue Therapien wieREVLIMID bieten den Patienten jedoch signifikant verlängerte Überlebenszeitenund verschieben die Krankheit eher in die Richtung einer chronischen,kontrollierbaren Erkrankung", erklärte Gareth Morgan, Professor für Hämatologie,Royal Marsden NHS Foundation Trust.

Wird keinEinspruch eingelegt, kann das NICE die Bewertung als Grundlage seinerendgültigen Richtlinie für den NHS verwenden, die für das zweite Quartal 2009erwartet wird. Le traduzioni sono offerte unicamente percomodità del lettore e devono rinviare al testo in lingua originale, che èl'unico giuridicamente valido. Le plasmacellule sono celluleematiche bianche che aiutano a produrre anticorpi, chiamati immunoglobuline, chea loro volta combattono le infezioni e diversi tipi di malattie. Informazioni sul mieloma multiploIl mieloma multiplo (altrimenti noto come mieloma o mieloma plasmacellulare) èun tumore del sangue in cui, a livello di midollo osseo, vengono prodotteelevate quantità di plasmacellule maligne. E` autorizzato in Australia eNuova Zelanda in combinazione con desametasone per il trattamento di pazienti lacui malattia sia progredita dopo una terapia.

"Accogliamo con soddisfazione il FAD positivo da parte del NICE e lodiamol'accento dall'organizzazione sull'aspetto organizzativo permettendo l`accesso aterapie che offrano ai pazienti nel Regno Unito una vita più lunga eproduttiva." ha commentato Sol J Barer, Ph.D., Chairman e CEO di CelgeneCorporation. La raccomandazione afferma inoltre che il costo del farmaco (esclusi i costicorrelati) per pazienti sottoposti ad oltre 26 cicli di terapia (ognuno di 28giorni, in genere per un periodo di due anni) sarà sostenuto da Celgene. Il NICEha stabilito che REVLIMID, una terapia innovativa in grado di prolungare lavita, costituisce un impiego economicamente efficace delle risorse dell`NHS. The calculation of Net Debt is shown below:Equipment Operations Financial Services ----------------------- -----------------------March 31,December 31,March 31, December 31, 20092008 2009 2008 ----------- ----------- ----------- -----------(in millions)Total Debt $ 4,503 $ 4,557 $ 8,486 $ 9,095Less:Cash and cash equivalents155 173 515 460Deposits in Fiat affiliates cash management pools1,079 1,666 373 392Intersegment notes receivables 2,381 2,295 - - ----------- ----------- ----------- -----------Net Debt $ 888 $ 423 $ 7,598 $ 8,243 =========== =========== =========== ===========Working CapitalEquipment Operations working capital is defined as accounts and notesreceivable and other-net, excluding intersegment notes receivable, plusinventories less accounts payable The U.S. Three Months Ended March 31,------------------------------- 20092008--------------- ---------------(in millions)Net sales $ 3,052100.0% $ 4,099100.0%Less:Cost of goods sold2,627 86.1% 3,399 82.9%------- -------Gross profit425 13.9% 700 17.1%Less:Selling, general and administrative 2939.6% 3308.1%Research and development 933.0% 1062.6%------- -------Industrial operating profit $391.3% $ 2646.4%======= =======Net DebtNet Debt is defined as total debt less cash and cash equivalents, depositsin Fiat affiliates cash management pools and intersegment notesreceivable. CNH defines Equipment Operations operatingmargin as operating profit as a percent of net sales of equipment. CNH does not expect a material impact to financial statementsfrom the final settlement of this matter.11.

The Tribunal inthe Arbitration issued a partial decision on liability issues in August2007, finding, among other things, that CNH was not permitted toterminate the Services Agreement and that PGN was entitled in principleto recover amounts properly owed to it at the time of termination as wellas additional damages that PGN may establish it suffered with respect tolost profits.In 2007 and 2008, CNH made payments to PGN in respect of certain unpaidinvoices claimed by PGN outside of the Arbitration, and claims which theTribunal held CNH was responsible for and with respect to which CNH didnot have an objection as to amount. Cash utilization recorded in first quarterof 2009 primarily represents payments of involuntary employee severancecosts and costs related to the closing of facilities 10. For 2009, the tax rate differs from the Netherlandsstatutory rate of 25.5% due primarily to the impact of tax losses incertain jurisdictions where no immediate tax benefit is recognized,provisioning of unrecognized tax benefits, and enacted changes in taxrates. The Australian warehousefacility limit increased by AUS $60 million to bring the facility fromAUS $440 million to AUS $500 million and an additional portfolio ofwholesale receivables was sold to factors in some European jurisdictions.5. A loss of $30 million wasincurred on the sales of these receivables.